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报告题目：Bone Tissue Engineering-the Next Frontier

报告人：Teoh Swee Hin教授 （湖南大学）

主持人：边黎明教授

报告时间：2023年7月12日（周三）上午10:00

报告地点：国际校区D1-b110报告厅

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                           生物医学科学与工程8297至尊品牌游戏官方网站

                               2023年7月7日   

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报告人简介：Prof Teoh is the Founding Director and Distinguished Changjiang Chair Professor, Center for Advanced Medical Engineering (CAME) at the College of Materials Science and Engineering, Hunan University, People's Republic of China. He majored in Materials Engineering (B Eng with First Class Honors and PhD at Monash University in 1978 and 1982 respectively). He is a Fellow of the Institution of Engineers, Singapore.
Prof Teoh spent 30 yrs (1982-2012) at the National University of Singapore (NUS) and Co-Chaired the Graduate Program in BioEngineering (GPBE). He also Chaired the School of Chemical and Biomedical Engineering (SCBE) with a joint Professorship at the Lee Kong Chian School of Medicine (LKC Med) at Nanyang Technological University (NTU), from 2012-2021. He was awarded the prestigious NTU President's Chair Award for Educational Leadership and for his outstanding research. He is also the Senior Mentor to the clinical scientists at the National Dental Centre of Singapore for the last 10 years. He is committed to using knowledge to benefit society. He is known for excellence in teaching, research and entrepreneurship.
Professor Teoh is a global leader and pioneer in the use of 3D printing technology to manufacture clinical scaffolds for bone tissue engineering. To date, his MedTech company Osteopore Internationals has implanted more than 60,000 scaffolds worldwide. The company has been successfully listed in 2019 (ASX-Australia). His pioneering work on 3D printed scaffolding has earned him the prestigious "Golden Innovation Award" from the Far Eastern Economic Review and the "Notable Engineering Achievement Award" from the Institute of Engineers, Singapore. As part of the SG50 celebrations, he was listed as one of Singapore's leading scientists. His team also received the "2018 Patent Excellence Award" from the Intellectual Property Office of Singapore.
Currently, he is focusing on biomaterials, piezoelectric bone tissue engineering and regenerative medicine with research ranging from synthetic bones, blood vessels and skin, to biomimetic bioreactors, to fish collagen, decellularized organs and effect of electromagnetic field on cells. He hopes to eventually translate them into the clinic. With more than 37 Ph.D. graduates, 270 research publications, and 22 patents and technical disclosures, Professor Teoh is a pioneer and outstanding educator with numerous teaching awards in materials science and engineering, bioengineering and translational tissue engineering and regenerative medicine.

报告摘要：The gold standard of bone graft materials has been autogenous bone as it contains viable cells (osteogenesis), growth factors such as bone morphogenic protein (BMP) (osteoinduction) and a large surface area for bone ingrowth (osteoconduction). However, the need of a second surgery, difficulty of shaping to specific defect and the possibility of resorption have damped the use and alternatives are being sort after. A rethinking is now needed especially in the role of lymphocytes such as neutrophils which is the first cells in any wound repair. Tissue engineering holds the key to body parts replacements. It involves a highly interdisciplinary team with biomaterials scientists, engineers in bioreactor technology and imaging experts in molecular cell biology as well as the important role of clinicians to provide expertise in surgical techniques and conducting clinical trials. Tissue engineering has been heralded as the new wave to revolutionise the healthcare-biotechnology industry especially with the new innovation in 3D printing technology. The aim of tissue engineering is to restore, maintain, or improve tissue and organ functions with minimal host rejection. The present talk will focus on the challenges and the next frontier in developing a platform technology which integrates biomaterials, medical imaging, advance manufacturing and electromagnetic field to produce 3D porous bioresorbable scaffolds for tissue engineering of bone as applied to dentistry, craniofacial surgery and long bone. Numerous clinical case studies will be shown. It has been well established, apart from biochemical, mechano-induction of osteoblast to express the appropriate extra cellular matrix needs to be addressed in the design of new load bearing scaffolds. The design philosophy of creating a bioresorbable scaffold with high surface energy, interconnected porosity that traps cells and promote angiogenesis, growth factors and eventually dissolves into carbon dioxide and water is elaborated. The use of bi-axial bioreactor to generate bone outside the body is illustrated. Bone is piezoelectric and recent work on applying electromagnetic field shows promising results and new thinking in bone grafting technology.